bone tissue response to porous and functionalized titanium and silica based coatings骨组织多孔和功能化钛及硅基涂料.pdfVIP

Bone Tissue Response to Porous and Functionalized Titanium and Silica Based Coatings 1 2 2 3 1 Amol Chaudhari , Annabel Braem , Jozef Vleugels , Johan A. Martens , Ignace Naert , Marcio Vivan 1 1 Cardoso , Joke Duyck * 1 Department of Prosthetic Dentistry, BIOMAT Research Group, K. U. Leuven, Leuven, Belgium, 2 Department of Metallurgy and Materials Engineering (MTM), K. U. Leuven, Heverlee, Belgium, 3 Centre of Surface Chemistry and Catalysis, K. U. Leuven, Heverlee, Belgium Abstract Background: Topography and presence of bio-mimetic coatings are known to improve osseointegration. The objective of this study was to evaluate the bone regeneration potential of porous and osteogenic coatings. Methodology: Six-implants [Control (CTR); porous titanium coatings (T1, T2); thickened titanium (Ti) dioxide layer (TiO ); 2 Amorphous Microporous Silica (AMS) and Bio-active Glass (BAG)] were implanted randomly in tibiae of 20-New Zealand white rabbits. The animals were sacrificed after 2 or 4 weeks. The samples were analyzed histologically and histomorphometrically. In the initial bone-free areas (bone regeneration areas (BRAs)), the bone area fraction (BAF) was evaluated in the whole cavity (500 mm, BAF-500), in the implant vicinity (100 mm, BAF-100) and further away (100–500 mm, BAF-400) from the implant. Bone-to-implant contact (BIC-BAA) was measured in the areas where the implants were installed in contact to the host bone (bone adaptation areas (BAAs)) to understand and compare the bone adaptation. Mixed models were