bone t-scores and functional status a cross-sectional study on german elderly骨t指数和功能状态对德国老人横断面研究.pdfVIP

Bone T-Scores and Functional Status: A Cross-Sectional Study on German Elderly 1 2 1 1 Shoma Berkemeyer *, Jochen Schumacher , Ulrich Thiem , Ludger Pientka 1 Department of Geriatrics, University of Bochum, Marienhospital Herne, Herne, Germany, 2 Department of Internal Medicine, Alfried Krupp Krankenhaus Steele, University of Duisburg-Essen, Essen, Germany Abstract Background: We explore the association between bone T-scores, used in osteoporosis diagnosis, and functional status since we hypothesized that bone health can impact elderly functional status and indirectly independence. Methods: In a cross-sectional study (2005–2006) on community dwelling elderly (. = 75 years) from Herne, Germany we measured bone T-scores with Dual-energy X-ray Absorptiometry, and functional status indexed by five geriatric tests: activities of daily living, instrumental activities of daily living, test of dementia, geriatric depression score and the timed-up- and-go test, and two pooled indexes: raw and standardized. Generalized linear regression was used to determine the relationship between T-scores and functional status. Results: From 3243 addresses, only 632 (19%) completed a clinical visit, of which only 440 (male:female, 243:197) could be included in analysis. T-scores (20.99, 95% confidence interval [CI], 21.1–0.9) predicted activities of daily living (95.3 CI, 94.5– 96.2), instrumental activities of daily living (7.3 CI, 94.5–96.2), and timed-up-and-go test (10.7 CI, 10.0–11.3) (P, = 0.05). Pooled data showed that a unit improvement in T-score improved standardized pooled functional status (15 CI, 14.7–15.3) by 0.41 and the raw (99.4 CI, 97.8–101.0) by 2.27 units. These results were limited due to pooling of differen