candida albicans interactions with bacteria in the context of human health and disease白色念珠菌与细菌的相互作用在人类健康和疾病.pdfVIP

Pearls Candida albicans Interactions with Bacteria in the Context of Human Health and Disease Diana K. Morales, Deborah A. Hogan* Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire, United States of America Humans are colonized by diverse populations of bacteria and assaults and facilitates different bacterial-fungal interactions [1,2]. fungi when in a healthy state and in the settings of disease, and the The known relationships between C. albicans and oral streptococci interactions between these microbial populations can be beneficial illustrate the various ways by which bacteria and fungi can attach or detrimental to the host [1]. Among these microbial populations, to one another or coaggregate using specific cell surface factors, Candida albicans is the fungus most commonly detected in leading to mixed-species biofilms [2,7]. These adhesive interac- association with humans [2], and numerous studies have described tions between C. albicans and other indigenous oral microbes can C. albicans interactions with its bacterial neighbors [1]. Here, with a be mediated by protein-protein and lectin-carbohydrate interac- focus on C. albicans, we provide examples of how bacterial-fungal tions, and hydrophobic and electrostatic interactions may interactions can influence human health. In addition, we highlight contribute as well. C. albicans molecules such as agglutinin-like studies that give insight into the molecular mechanisms that sequences (Als) and specific cell surface glycoproteins have been govern the physical associations, interspecies communication, and identified as being important for coadhesion to mixed microbial changes in micro