candidate polymorphisms and severe malaria in a malian population候选人多态性和严重疟疾在马里的人口.pdfVIP

Candidate Polymorphisms and Severe Malaria in a Malian Population 1 1 1 1 1,2 Ousmane Toure , Salimata Konate , Sibiri Sissoko , Amadou Niangaly , Abdoulaye Barry , 1,2 1,2 1 3 4 Abdourahmane H. Sall , Elisabeth Diarra , Belco Poudiougou , Nuno Sepulveda , Susana Campino , 5 3,6 . 1 . 1 . Kirk A. Rockett , Taane G. Clark * , Mahamadou A. Thera * , Ogobara Doumbo * , in collaboration with The MalariaGEN Consortium4,5 1 Malaria Research and Training Centre, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali, 2 Centre hospitalier Universitaire Gabriel Toure Hospital, Bamako, Mali, 3 Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom, 4 Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom, 5 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, 6 Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom Abstract Malaria is a major health burden in sub-Saharan African countries, including Mali. The disease is complex, with multiple genetic determinants influencing the observed variation in response to infection, progression, and severity. We assess the influence of sixty-four candidate loci, including the sickle cell polymorphism (HbS), on severe malaria in a case-co