cluster analysis of obesity and asthma phenotypes肥胖与哮喘表型聚类分析.pdfVIP

Cluster Analysis of Obesity and Asthma Phenotypes 1,4 2 3 3 1 2 E. Rand Sutherland *, Elena Goleva , Tonya S. King , Erik Lehman , Allen D. Stevens , Leisa P. Jackson , 4 5 2,4 for the Asthma Clinical Research Network Amanda R. Stream , John V. Fahy , Donald Y. M. Leung 1 Department of Medicine, National Jewish Health, Denver, Colorado, United States of America, 2 Department of Pediatrics, National Jewish Health, Denver, Colorado, United States of America, 3 Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America, 4 Department of Medicine, University of Colorado, Denver, Colorado, United States of America, 5 Department of Medicine, University of California San Francisco, San Francisco, California, United States of America, 6 Department of Medicine, University of Colorado, Denver, Colorado, United States of America Abstract Background: Asthma is a heterogeneous disease with variability among patients in characteristics such as lung function, symptoms and control, body weight, markers of inflammation, and responsiveness to glucocorticoids (GC). Cluster analysis of well-characterized cohorts can advance understanding of disease subgroups in asthma and point to unsuspected disease mechanisms. We utilized an hypothesis-free cluster analytical approach to define the contribution of obesity and related variables to asthma phenotype. Methodology and Principal Findings: In a cohort of clinical trial participants (n = 250), minimum-variance hierarchical clustering was used to identify clinical and inflammatory biomarkers important in determining disease cluster