comprehensive analysis of common serum liver enzymes as prospective predictors of hepatocellular carcinoma in hbv patients综合分析共同血清肝酶的乙肝患者的肝细胞癌的前瞻性预测.pdfVIP

Comprehensive Analysis of Common Serum Liver Enzymes as Prospective Predictors of Hepatocellular Carcinoma in HBV Patients 1. 2. 2 1 3 2 Hie-Won Hann , Shaogui Wan , Ronald E. Myers , Richard S. Hann , Jinliang Xing , Bicui Chen , Hushan Yang2* 1 Division of Gastroenterology and Hepatology, Department of Medicine, Liver Disease Prevention Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, 2 Division of Population Science, Department of Medical Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, 3 State Key Laboratory of Cancer Biology, Cell Engineering Research Centre and Department of Cell Biology, Fourth Military Medical University, Xi’an, China Abstract Background: Serum liver enzymes are frequently tested in clinics to aid disease diagnosis. Large observational studies indicated that these enzymes might predict cancer risk and mortality. However, no prospective study has reported on their relationships with the risk of HBV-related hepatocellular carcinoma (HCC). Methodology/Principal Findings: We evaluated the predictive values of four routinely tested liver enzymes (alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline phosphatase [ALP], and gamma-glutamyltransferase [GGT]) in HCC risk in a prospectively enrolled clinical cohort of 588 Korean American HBV patients. For all four enzymes, the baseline level as well as the average and maximum levels during the first 1 or 2 years of follow-up were analyzed using multivariate Cox proportional hazards model. Patients were categorized into a normal or an elevated group based on the cli