comprehensive biostatistical analysis of cpg island methylator phenotype in colorectal cancer using a large population-based sample综合biostatistical cpg岛methylator表型的分析结直肠癌使用大样本人群为基础的.pdfVIP

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comprehensive biostatistical analysis of cpg island methylator phenotype in colorectal cancer using a large population-based sample综合biostatistical cpg岛methylator表型的分析结直肠癌使用大样本人群为基础的.pdf

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comprehensive biostatistical analysis of cpg island methylator phenotype in colorectal cancer using a large population-based sample综合biostatistical cpg岛methylator表型的分析结直肠癌使用大样本人群为基础的

Comprehensive Biostatistical Analysis of CpG Island Methylator Phenotype in Colorectal Cancer Using a Large Population-Based Sample 1. 1. 1. 1. 2 Katsuhiko Nosho , Natsumi Irahara , Kaori Shima , Shoko Kure , Gregory J. Kirkner , Eva S. Schernhammer2,3,4, Aditi Hazra2,4, David J. Hunter2,4, John Quackenbush 5,6, Donna Spiegelman2,4,6, Edward L. Giovannucci2,4, Charles S. Fuchs1,2, Shuji Ogino1,4,7* 1 Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, United States of America, 2 Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, 3 Ludwig Boltzmann-Institute for Applied Cancer Research, and Applied Cancer Research – Institute for Translational Research, Vienna, Austria, 4 Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, 5 Department of Biostatistics, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, United States of America, 6 Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America, 7 Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America Abstract Background: The CpG island methylator phenotype (CIMP) is a distinct phenotype associated with microsatellite instability (MSI) and BRAF mutation in colon cancer. Recent investigations have selected 5 promoters (CACNA1G, IGF2, NEUROG1, RUNX3 and SOCS1) as surrogate markers for CIMP-high. However, no study has comprehensively evaluated an expanded set of methylation markers (including these 5 markers) using a large numb