comprehensive decision tree models in bioinformatics在生物信息学综合决策树模型.pdfVIP

Comprehensive Decision Tree Models in Bioinformatics 1,2 1 1 1,2 Gregor Stiglic *, Simon Kocbek , Igor Pernek , Peter Kokol 1 Faculty of Health Sciences, University of Maribor, Maribor, Slovenia, 2 Faculty of Electrical Engineering and Computer Science, University of Maribor, Maribor, Slovenia Abstract Purpose: Classification is an important and widely used machine learning technique in bioinformatics. Researchers and other end-users of machine learning software often prefer to work with comprehensible models where knowledge extraction and explanation of reasoning behind the classification model are possible. Methods: This paper presents an extension to an existing machine learning environment and a study on visual tuning of decision tree classifiers. The motivation for this research comes from the need to build effective and easily interpretable decision tree models by so called one-button data mining approach where no parameter tuning is needed. To avoid bias in classification, no classification performance measure is used during the tuning of the model that is constrained exclusively by the dimensions of the produced decision tree. Results: The proposed visual tuning of decision trees was evaluated on 40 datasets containing classical machine learning problems and 31 datasets from the field of bioinformatics. Although we did not expected significant differences in classification performance, the results demonstrate a significant increase of accuracy in less complex visually tuned decision trees. In contrast to classical machine learning benchmarking datasets, we observe higher accuracy gains in bioinformatics datasets. Additionally, a user study was carried out to confirm the assumption