coordinated regulation of siv replication and immune responses in the cns协调监管猴免疫缺陷病毒复制和中枢神经系统的免疫反应.pdfVIP

Coordinated Regulation of SIV Replication and Immune Responses in the CNS 1 1 1 1 1 Kenneth W. Witwer , Lucio Gama , Ming Li , Christopher M. Bartizal , Suzanne E. Queen , John J. 1 1 1,4 5 1,2,3 Varrone , Angela K. Brice , David R. Graham , Patrick M. Tarwater , Joseph L. Mankowski , M. Christine Zink1,2, Janice E. Clements1,2,3* 1 Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 2 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 3 Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 4 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 5 Department of Biomedical Sciences, Texas Tech University Health Sciences Center, El Paso,Texas, United States of America Abstract Central nervous system (CNS) invasion during acute-stage HIV-infection has been demonstrated in a small number of individuals, but there is no evidence of neurological impairment at this stage and virus infection in brain appears to be controlled until late-stage disease. Using our reproducible SIV macaque model to examine the earliest stages of infection in the CNS, we identified immune responses that differentially regulate inflammation and virus replication in the brain compared to the peripheral blood and lymphoid tissues. SIV replication in brain macrophages and in brain of SIV-infected macaques