cryptococcal neuroradiological lesions correlate with severity during cryptococcal meningoencephalitis in hiv-positive patients in the haart era隐球菌脑膜炎中隐球菌neuroradiological病变严重程度与鸡尾酒疗法的hiv阳性患者体内的时代.pdfVIP
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cryptococcal neuroradiological lesions correlate with severity during cryptococcal meningoencephalitis in hiv-positive patients in the haart era隐球菌脑膜炎中隐球菌neuroradiological病变严重程度与鸡尾酒疗法的hiv阳性患者体内的时代
Cryptococcal Neuroradiological Lesions Correlate with
Severity during Cryptococcal Meningoencephalitis in
HIV-Positive Patients in the HAART Era
1,2 1 ´ ˆ 3 ¨ 4 ´
Caroline Charlier , Franc¸oise Dromer , Christophe Leveque , Loıc Chartier , Yves-Sebastien
Cordoliani3, Arnaud Fontanet4, Odile Launay5, Olivier Lortholary 1,2* for the French Cryptococcosis
Study Group
´ ´ ´ ´ ´ ´
1 Centre National de Reference Mycologie et Antifongiques, Unite de Mycologie Moleculaire, CNRS URA 3012, Institut Pasteur, Paris, France, 2 Faculte de Medecine Paris V
´ ˆ
Rene Descartes, Hopital Necker-Enfants Malades, Service des Maladies Infectieuses et Tropicales, Centre d’Infectiologie Necker-Pasteur, Paris, France, 3 Service de
ˆ ˆ ´ ´
Radiodiagnostic, Hopital du Val de Grace, Paris, France, 4 Unite de Recherche et d’Expertise en Epidemiologie des Maladies Emergentes, Institut Pasteur, Paris, France,
´ ´ ´ ˆ ˆ ´
5 Universite Paris-Descartes, Faculte de Medecine, Hopital Cochin, Pole de Medecine Interne, CIC de Vaccinologie Cochin-Pasteur, Paris, France
Abstract
Cryptococcal meningoencephalitis has an overall global mortality rate of 20% in AIDS patients despite antifungals. There is a
need for additional means of precise assessment of disease severity. We thus studied the radiological brain images available
from 62 HIV-positive patients with cryptococcocal meningoencephalitis to analyse the brain
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