原创力文档cryptolepine-induced cell death of leishmania donovani promastigotes is augmented by inhibition of autophagycryptolepine-induced杜氏利什曼虫的细胞死亡promastigotes被抑制自噬增强.pdfVIP
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cryptolepine-induced cell death of leishmania donovani promastigotes is augmented by inhibition of autophagycryptolepine-induced杜氏利什曼虫的细胞死亡promastigotes被抑制自噬增强
SAGE-Hindawi Access to Research
Molecular Biology International
Volume 2011, Article ID 187850, 12 pages
doi:10.4061/2011/187850
Research Article
Cryptolepine-Induced Cell Death of Leishmania donovani
Promastigotes Is Augmented by Inhibition of Autophagy
Souvik Sengupta,1 Sayan Chowdhury,1 Somdeb BoseDasgupta,2 Colin W. Wright,3
and Hemanta K. Majumder1
1 Molecular Parasitology Laboratory, Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Jadavpur,
Kolkata 700032, India
2 Infection Biology, Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland
3 Bradford School of Pharmacy, University of Bradford, West Yorkshire BD7 1DP, UK
Correspondence should be addressed to Hemanta K. Majumder, hkmajumder@iicb.res.in
Received 24 November 2010; Accepted 12 January 2011
Academic Editor: Wanderley De Souza
Copyright © 2011 Souvik Sengupta et al. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
Leishmania donovani are the causative agents of visceral leishmaniasis worldwide. Lack of vaccines and emergence of drug
resistance warrants the need for improved drug therapy and newer therapeutic intervention strategies against leishmaniasis. In
the present study, we have investigated the effect of the natural indoloquinoline alkaloid cryptolepine on L. donovani AG83
promastigotes. Our results show that cryptolepine induces cellular dysfunction in L. donovani promastigotes, which leads to
the death of this unicellular parasite. Interestingly, our study suggest that cryptolepine-induced cell death of L.
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