原创力文档cryptopleurine targets nf-κb pathway, leading to inhibition of gene products associated with cell survival, proliferation, invasion, and angiogenesiscryptopleurine目标nf-κb通路,从而抑制基因产物与细胞生存、增殖,入侵和血管生成.pdfVIP
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cryptopleurine targets nf-κb pathway, leading to inhibition of gene products associated with cell survival, proliferation, invasion, and angiogenesiscryptopleurine目标nf-κb通路,从而抑制基因产物与细胞生存、增殖,入侵和血管生成
Cryptopleurine Targets NF-kB Pathway, Leading to
Inhibition of Gene Products Associated with Cell
Survival, Proliferation, Invasion, and Angiogenesis
3. 2. 3 1 1 1 1,3
Hong Ri Jin , Song Zhu Jin , Xing Fu Cai , Donghao Li , Xue Wu , Ji Xing Nan , Jung Joon Lee *,
Xuejun Jin1*
1 Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Yanbian University, Ministry of Education, Yanji, Jilin, China, 2 Department of
Immunology and Pathogenic Biology, College of Basic Medicine, Yanbian University, Yanji, Jilin, China, 3 Center for Molecular Cancer Research, Korea Research Institute of
Bioscience and Biotechnology, Ochang, Chungbuk, Republic of Korea
Abstract
Background: Cryptopleurine, a phenanthroquinolizidine alkaloid, was known to exhibit anticancer activity; however, the
underlying mechanism is poorly understood. Because the nuclear factor-kB (NF-kB) transcription factors control many
physiological processes including inflammation, immunity, and development and progression of cancer, we investigated
the effects of cryptopleurine on tumor necrosis factor alpha (TNF-a)-induced NF-kB activation pathway and on the
expression of NF-kB-regulated gene products associated with many pathophysiological processes.
Methodology and Principal Finding: MDA-MB231, MDA-MB435, MCF-7, HEK293, RAW264.7 and Hep3B cells were used to
examine cryptopleurine’s effect on the NF-kB activation pathway. Major assays were promoter-reporter gene assay,
electrophoretic mobility shift assay (EMSA), in vitro immune complex kinase assay, real-time PCR, Western blot analysis, and
Matrigel invasion assay. Experiments d
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