cxcl17 expression by tumor cells recruits cd11b+gr1highf480？ cells and promotes tumor progressioncxcl17肿瘤细胞表达的新兵cd11b + gr1highf480 细胞和促进肿瘤的进展.pdfVIP

CXCL17 Expression by Tumor Cells Recruits CD11b+Gr1highF4/802 Cells and Promotes Tumor Progression 1,2 3 4 4 2 Aya Matsui , Hideaki Yokoo , Yoichi Negishi , Yoko Endo-Takahashi , Nicole A. L. Chun , 2 5 5 5 6 7 Ichiro Kadouchi , Ryo Suzuki , Kazuo Maruyama , Yukihiko Aramaki , Kentaro Semba , Eiji Kobayashi , 2 1 Masafumi Takahashi , Takashi Murakami * 1 Laboratory of Tumor Biology, Takasaki University of Health and Welfare, Takasaki, Gunma, Japan, 2 Division of Bioimaging Sciences, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan, 3 Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan, 4 Department of Drug and Gene Delivery Systems, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan, 5 Department of Biopharmaceutics, School of Pharmaceutical Sciences, Teikyo University, Sagamihara, Kanagawa, Japan, 6 Department of Life Science and Medical Bio-Science, Waseda University, Wakamatsu, Shinjuku, Tokyo, Japan, 7 Division of Development for Advanced Medical Technology, Jichi Medical University, Shimotsuke, Tochigi, Japan Abstract Background: Chemokines are involved in multiple aspects of pathogenesis and cellular trafficking in tumorigenesis. In this study, we report that the latest member of the C-X-C-type chemokines, CXCL17 (DMC/VCC-1), recruits immature myeloid- derived cells and enhances early tumor progression. Methodology/Principal Findings: CXCL17 was preferentially expressed in some aggre