coping with viral diversity in hiv vaccine design a response to nickle et al.应对病毒多样性在艾滋病疫苗设计应对镍等。.pdfVIP

Correspondence Coping with Viral Diversity in recombined natural sequences, the algorithm proceeds by a series of iterations of recombination and selection, HIV Vaccine Design: optimizing for 9-mer coverage of the input sequences. The result is a small set of full-length protein sequences that A Response to Nickle et al. collectively approach the upper bound on coverage Will Fischer, H. X. Liao, Barton F. Haynes, attainable for a given number of proteins [2]. Norman L. Letvin, Bette Korber We designed a three-mosaic protein set using the same input data as Nickle et al. to directly compare the two Nickle et al. [1] recently reported a computational method methods using the same metric as Nickle et al. The mosaic set, for HIV-1 vaccine antigen design; here we compare this despite being constrained to use full-length proteins, method with our previously published vaccine antigen design performed slightly better in terms of 9-mer coverage than method [2], using several criteria that we believe to be three protein lengths using COTþ (Figure 2). The mosaics important for a successful vaccine candidate [2]. The intent of used three full-length protein sequen