copeptin, procalcitonin and routine inflammatory markers–predictors of infection after strokecopeptin,原降钙素和常规炎症markers-predictors卒中后感染.pdfVIP

Copeptin, Procalcitonin and Routine Inflammatory Markers–Predictors of Infection after Stroke 1,2 3 4 5 2,6 Felix Fluri *, Nils G. Morgenthaler , Beat Mueller , Mirjam Christ-Crain , Mira Katan ¨ ¨ ¨ 1 Department of Neurology, University Hospital Basel, Basel, Switzerland, 2 Department of Neurology, University Hospital Zurich, Zurich, Switzerland, 3 Institut fur ´ Experimentelle Endokrinologie, Charite, Berlin, Germany, 4 Medical University Clinic, Cantonal Hospital Aarau, Aarau, Switzerland, 5 Department of Endocrinology, University Hospital Basel, Basel, Switzerland, 6 Columbia University, Department of Neurology, Division of Stroke, New York, New York, United States of America Abstract Background: Early predictors for the development of stroke-associated infection may identify patients at high risk and reduce post-stroke infection and mortality. Methods: In 383 prospectively enrolled acute stroke patients we assessed time point and type of post-stroke infections (i.e. pneumonia, urinary tract infection (UTI) other infection (OI)). Blood samples were collected on admission, and days 1, and 3 to assess white blood cells (WBC), monocytes, C-reactive protein (CRP), procalcitonin (PCT), and copeptin. To determine the magnitude of association with the development of infections, odds ratios (OR) were calculated for each prognostic blood marker. The discriminatory ability of different predictors was assessed, by calculating area under the receiver operating characteristic curves (AUC). Prognostic models incl