comparative gene expression analysis throughout the life cycle of leishmania braziliensis diversity of expression profiles among clinical isolates比较基因表达分析在整个生命周期的利什曼虫braziliensis临床分离株中表达谱的多样性.pdfVIP

Comparative Gene Expression Analysis throughout the Life Cycle of Leishmania braziliensis: Diversity of Expression Profiles among Clinical Isolates 1,2 1,3 3 3 2 Vanessa Adaui , Denis Castillo , Mirko Zimic , Andres Gutierrez , Saskia Decuypere , Manu 2,4 2 2,4 2 2 Vanaerschot , Simonne De Doncker , Kathy Schnorbusch , Ilse Maes , Gert Van der Auwera , Louis 4 1 1,3 2,4 Maes , Alejandro Llanos-Cuentas , Jorge Arevalo , Jean-Claude Dujardin * 1 Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru, 2 Unit of Molecular Parasitology, Department of ´ ´ Parasitology, Institute of Tropical Medicine, Antwerp, Belgium, 3 Laboratorios de Investigacion y Desarrollo, Facultad de Ciencias y Filosofıa, Universidad Peruana Cayetano Heredia, Lima, Peru, 4 Department of Biomedical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium Abstract Background: Most of the Leishmania genome is reported to be constitutively expressed during the life cycle of the parasite, with a few regulated genes. Inter-species comparative transcriptomics evidenced a low number of species-specific differences related to differe