原创力文档cystathionine beta-synthase deficiency causes fat loss in mice胱硫醚beta-synthase不足导致小鼠脂肪损失.pdfVIP
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cystathionine beta-synthase deficiency causes fat loss in mice胱硫醚beta-synthase不足导致小鼠脂肪损失
Cystathionine Beta-Synthase Deficiency Causes Fat Loss
in Mice
Sapna Gupta, Warren D. Kruger*
Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
Abstract
Cystathionine beta synthase (CBS) is the rate-limiting enzyme responsible for the de novo synthesis of cysteine. Patients with
CBS deficiency have greatly elevated plasma total homocysteine (tHcy), decreased levels of plasma total cysteine (tCys), and
often a marfanoid appearance characterized by thinness and low body-mass index (BMI). Here, we characterize the gro
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