deficiency of activating fcγ-receptors reduces hepatic clearance and deposition of ic and increases cic levels in mercury-induced autoimmunity缺乏激活fcγ-receptors减少肝脏清除率和沉积的ic和增加中投在mercury-induced自身免疫水平.pdfVIP

Deficiency of Activating Fcc-Receptors Reduces Hepatic Clearance and Deposition of IC and Increases CIC Levels in Mercury-Induced Autoimmunity 1 ¤ 2 4 5 ¨ 3 Klara Martinsson * , Thomas Skogh , Seyed Ali Mousavi , Trond Berg , Jan-Ingvar Jonsson , Per Hultman1 ¨ ¨ 1 Division of Molecular and Immunological Pathology (AIR), Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden, 2 Rheumatology ¨ ¨ Unit (AIR), Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden, 3 Experimental Hematology Unit, Department of Clinical and ¨ ¨ Experimental Medicine, Linkoping University, Linkoping, Sweden, 4 Medical Genetics Laboratory, Department of Medical Genetics, Rikshospitalet University Hospital, Oslo, Norway, 5 Department of Molecular Biosciences, University of Oslo, Oslo, Norway Abstract Background: Inorganic mercury (Hg) induces a T-cell dependent, systemic autoimmune condition (HgIA) where activating Fcc-receptors (FccRs) are important for the induction. In this study we examined the influence of activating FccRs on circulating levels and organ localization of immune complexes (IC) in HgIA. Methods and Principal Findings: Mercury treated BALB/c wt mice showed a significant but modest increase of circulating IC (CIC) from day 12 until day 18 and day 35 for IgG2a- and IgG1- CIC, respectively. Mercury-treated mice lacking the trans- membrane c-chain of activating FccRs (FcRc2/ 2) had significantly higher CIC lev