critical transition in tissue homeostasis accompanies murine lung senescence关键在组织内稳态过渡伴随小鼠肺衰老.pdfVIP

Critical Transition in Tissue Homeostasis Accompanies Murine Lung Senescence 1. 1. 1 1 1 Carla L. Calvi , Megan Podowski , Franco R. D’Alessio , Shana L. Metzger , Kaori Misono , Hataya 1 1 1 2 3 Poonyagariyagorn , Armando Lopez-Mercado , Therese Ku , Thomas Lauer , Christopher Cheadle , C. 4 4 2 1 5 Conover Talbot Jr. , Chunfa Jie , Sharon McGrath-Morrow , Landon S. King , Jeremy Walston , Enid R. Neptune1* 1 Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 2 Pediatric Pulmonary, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 3 Lowe Family Genomics Core, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 4 JHMI Microarray Core, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 5 Division of Geriatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America Abstract Background: Respiratory dysfunction is a major contributor to morbidity and mortality in aged populations. The susceptibility to pulmonary insults is attributed to ‘‘low pulmonary reserve’’, ostensibly reflecting a combination of age- related musculoskeletal, immunologic and intrinsic pulmonary dysfunction. Methods/Principal Findings: Using a m