defining emerging roles for nf-κb in antivirus responses revisiting the interferon-β enhanceosome paradigm定义新兴角色在杀毒反应回顾nf-κb interferon-βenhanceosome范例.pdfVIP

Opinion Defining Emerging Roles for NF-kB in Antivirus Responses: Revisiting the Interferon-b Enhanceosome Paradigm 1 2 Siddharth Balachandran *, Amer A. Beg * 1 Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America, 2 Department of Immunology, H. Lee Moffitt Cancer Center, Tampa, Florida, United States of America Introduction Unexpected Results from NF-kB an in silico approach to analyze cells Gene-Targeted Mice deficient in RelA (the primary transacti- Classic studies over the last two decades vating component of virus-induced NF- have made virus-induced activation of the Given that IRFs-3/7, NF-kB, and ATF- kB), we have found that NF-kB controls mammalian interferon-b (ifnb) gene a pro- 2/c-Jun assemble on the ifnb enhancer, it expression of several IFN-dependent in- totype of eukaryotic gene regulation [1–6]. was expected that all three factors would be nate immune pathways by, unexpectedly, Indeed, the compact ,50 base-pair en- critical for virus-triggered induction of ifnb. maintaining constitutive expression of ifnb in hancer region upstream of the ifnb tran- In line with this expectation, studies using uninfected cells [16]. scription start site is amongst the best- mice deficient in IRF-3 and/or IRF-7 have It has long been known that constitutive studied stretches of mammalian DNA, and