dementia and depression with ischemic heart disease a population-based longitudinal study comparing interventional approaches to medical management痴呆与缺血性心脏病和抑郁症以人群为基础的纵向研究比较介入医疗管理方法.pdfVIP

Dementia and Depression with Ischemic Heart Disease: A Population-Based Longitudinal Study Comparing Interventional Approaches to Medical Management 1 2 3 2 2 W. Alan C. Mutch *, Randall R. Fransoo , Barry I. Campbell , Dan G. Chateau , Monica Sirski , R. Keith Warrian4 1 Department of Anesthesia and Peri-operative Medicine, Health Sciences Centre, University of Manitoba, Winnipeg, Manitoba, Canada, 2 Department of Community Health Sciences, Manitoba Centre for Health Policy, University of Manitoba, Winnipeg, Manitoba, Canada, 3 Department of Psychiatry, St. Boniface General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada, 4 Cardiac Sciences, Department of Surgery, St. Boniface General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada Abstract Background: We compared the proportion of ischemic heart disease (IHD) patients newly diagnosed with dementia and depression across three treatment groups: percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG) and medical management alone (IHD-medical). Methods and Findings: De-identified, individual-level administrative records of health service use for the population of Manitoba, Canada (approximately 1.1 million) were examined. From April 1, 1993 to March 31, 1998, patients were identified with a diagnosis of IHD (ICD-9-CM codes). Index events of CABG or PCI were identified from April 1, 1998 to March 31, 2003. Outcomes were depression or dementia after the index event. Patients were followed forward to March 31, 2006 or until censored. Proportional hazards regression analysis was undertaken. Independent variables examined were age, sex, diabetes, hypertension and