dendritic cell status modulates the outcome of hiv-related b cell disease progression树突细胞状态调节与艾滋病毒相关的b细胞疾病进展的结果.pdfVIP

Opinion Dendritic Cell Status Modulates the Outcome of HIV-Related B Cell Disease Progression Johanne Poudrier1,2*, Michel Roger1,2* ´ ´ ´ ´ ´ ´ ´ 1 Laboratoire d’immunogenetique, Centre de Recherche du Centre Hospitalier de l’Universite de Montreal (CHUM), Montreal, Quebec, Canada, 2 Departement de ´ ´ ´ ´ Microbiologie et Immunologie de l’Universite de Montreal, Montreal, Quebec, Canada derived DCs over express BLyS [14,15]. CD11c+ + 2 The overall outcome of HIV disease CD14 CD16 monocytic DC- may depend on the host’s capacity to Interestingly, AIRE is involved in regula- precursors [2]; the latter have been shown maintain dendritic cell (DC) homeostasis tion of STAT1 signalling, a pathway also to be associated with inflammatory condi- at mucosal sites, where DC populations, used by HIV-Nef to promote pro-inflam- tions [24]. In these subjects, B cell dysre- one of the earliest cell types to be exposed matory monocytes in humans [16,17] and gulation was found throughout disease to the virus, present an inherent capacity likely over expression of tumour necrosis progression and was accompanied by the to modulate the balance between toler- factor (TNF)-a by DCs [18]. HIV-gp120 increased frequency of a population pre- ance and protection. DCs may influence can also