dengue in thailand and cambodia an assessment of the degree of underrecognized disease burden based on reported cases登革热在泰国和柬埔寨underrecognized疾病负担程度的评估基于报告病例.pdfVIP

Dengue in Thailand and Cambodia: An Assessment of the Degree of Underrecognized Disease Burden Based on Reported Cases 1 2 3 4 2 Ole Wichmann *, In-Kyu Yoon , Sirenda Vong , Kriengsak Limkittikul , Robert V. Gibbons , Mammen P. 2 3 3 4 5 6 Mammen , Sowath Ly , Philippe Buchy , Chukiat Sirivichayakul , Rome Buathong , Rekol Huy , G. William Letson1, Arunee Sabchareon4 1 Pediatric Dengue Vaccine Initiative, International Vaccine Institute (IVI), Seoul, Korea, 2 Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand, 3 Institut Pasteur in Cambodia, Phnom Penh, Cambodia, 4 Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, 5 Bureau of Epidemiology, Ministry of Public Health, Nonthaburi, Thailand, 6 National Dengue Control Program, Ministry of Health, Phnom Penh, Cambodia Abstract Background: Disease incidence data are needed to guide decision-making for public health interventions. Although dengue is a reportable disease in Thailand and Cambodia, the degree that reported incidence underrecognizes true disease burden is unknown. We utilized dengue incidence calculated from laboratory-confirmed outpatient and inpatient cases in prospective cohort studies to estimate the magnitude of dengue underrecognition and to establish more accurate disease burden estimates for these countries. Methods and Findings: Cohort studies were conducted among children aged ,15 years by members of a dengue field site consortium over at least 2 dengue seasons. Age-group specific multiplication factors (MFs) were computed b