dengue incidence in urban and rural cambodia results from population-based active fever surveillance, 2006–2008登革热发病率在城乡柬埔寨人口活跃发烧监测结果,2006 - 2008.pdfVIP

Dengue Incidence in Urban and Rural Cambodia: Results from Population-Based Active Fever Surveillance, 2006– 2008 1 1 1 1 1 2 2 Sirenda Vong *, Virak Khieu , Olivier Glass , Sowath Ly , Veasna Duong , Rekol Huy , Chantha Ngan , 3 3 3 1 Ole Wichmann , G. William Letson , Harold S. Margolis , Philippe Buchy 1 Institut Pasteur–Cambodia, Phnom Penh, Cambodia, 2 National Dengue Control Program, National Center of Parasitology, Entomology and Malaria Control, Ministry of Health, Phnom Penh, Cambodia, 3 Pediatric Dengue Vaccine Initiative, International Vaccine Institute, Seoul, Korea Abstract Background: Dengue vaccines are now in late-stage development, and evaluation and robust estimates of dengue disease burden are needed to facilitate further development and introduction. In Cambodia, the national dengue case-definition only allows reporting of children less than 16 years of age, and little is known about dengue burden in rural areas and among older persons. To estimate the true burden of dengue in the largest province of Cambodia, Kampong Cham, we conducted community-based active dengue fever surveillance among the 0-to-19–year age group in rural villages and urban areas during 2006–2008. Methods and Findings: Active surveillance for febrile illness was conducted in 32 villages and 10 urban areas by mothers trained to use digital thermometers combined with weekly home visits to identify persons with fever. An investigation team visited families with febrile persons to obtain informed consent for participation in the follow-up study, which included collection of personal data and blood specimens. Dengue-related