dengue infection in children in ratchaburi, thailand a cohort study. ii. clinical manifestations登革热感染儿童叻武里,泰国一个队列研究。.pdfVIP

Dengue Infection in Children in Ratchaburi, Thailand: A Cohort Study. II. Clinical Manifestations 1 1 1 2 Chukiat Sirivichayakul *, Kriengsak Limkittikul , Pornthep Chanthavanich , Vithaya Jiwariyavej , 1 1 3 2 Watcharee Chokejindachai , Krisana Pengsaa , Saravudh Suvannadabba , Wut Dulyachai , G. William Letson4, Arunee Sabchareon1 1 Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, 2 Ratchaburi Hospital, Ministry of Public Health, Ratchaburi, Thailand, 3 Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand, 4 International Public Health Consultant, Denver, Colorado, United States of America Abstract Background: Dengue infection is one of the most important mosquito-borne diseases. More data regarding the disease burden and the prevalence of each clinical spectrum among symptomatic infections and the clinical manifestations are needed. This study aims to describe the incidence and clinical manifestations of symptomatic dengue infection in Thai children during 2006 through 2008. Study Design: This study is a school-based prospective open cohort study with a 9,448 person-year follow-up in children aged 3–14 years. Active surveillance for febrile illnesses was done in the studied subjects. Subjects who had febrile illness were asked to visit the study hospital for clinical and laboratory evaluation, treatment, and serological tests for dengue infection. The clinical data from medical records, diary cards, and data collection forms were collected and analyzed. Results: Dengue in