dental occlusion in a split amazon indigenous population genetics prevails over environment牙齿咬合在分割亚马逊土著群体遗传学盛行的环境.pdfVIP

Dental Occlusion in a Split Amazon Indigenous Population: Genetics Prevails over Environment 1 2 ˜ 3 ´ ˜ 4 David Normando *, Jorge Faber , Joao Farias Guerreiro , Catia Cardoso Abdo Quintao ´ 1 Department of Orthodontics, Dental School, Federal University of Para, Belem, Brasil, 2 Department of Orthodontics, Faculty of Health Science, University of Brasilia, ´ Brasilia, Brasil, 3 Laboratory of Human and Medical Genetics, Center of Biological Sciences, Federal University of Para, Belem, Brasil, 4 Department of Orthodontics, Dental School, State University of Rio de Janeiro, Rio de Janeiro, Brasil Abstract Background: Studies examining human and nonhuman primates have supported the hypothesis that the recent increase in the occurrence of misalignment of teeth and/or incorrect relation of dental arches, named dental malocclusion, is mainly attributed to the availability of a more processed diet and the reduced need for powerful masticatory action. For the first time on live human populations, genetic and tooth wear influences on occlusal variation were examined in a split indigenous population. The Arara-Iriri people are descendants of a single couple expelled from a larger village. In the resultant village, expansion occurred through the mating of close relatives, resulting in marked genetic cohesion with substantial genetic differences. Methodology/Principal Findings: Dental malocclusion, tooth wear and inbreeding coefficient were evaluated. The sample examined was composed of 176 individual