depositing a histone that protects active chromosomal regions from silencing存放保护积极的组蛋白染色体区域从沉默.pdfVIP

Research Digest Synopses of Research Articles Depositing a Histone That Protects Active Chromosomal Regions from Silencing When James Watson and Francis function depends largely on activating SWR1-Com. The largest subunit of this Crick reported the structure of DNA in the right gene at the right time, complex, called Swr1p, belongs to a well- 1953, the mechanism of inheritance was mechanisms have evolved that protect known family of adenosine triphosphate instantly apparent. The complementary active genes from the intrusions of (ATP)-dependent chromatin remodeling pairing of the DNA bases in the silencing structures like heterochromatin. enzymes (they use the energy of ATP to double helix, the pair famously wrote, power remodeling) that provide access “immediately suggests a possible to DNA in chromatin. Rine, Madhani, and copying mechanism for the genetic colleagues show that protein subunits of material.’’ The structure helped explain SWR1-Com associate specifi cally with the one of the central problems of modern histone variant H2A.Z. By comparing the biology: how does genetic material get gene expression profi les of yeast mutants faithfully replicated and then passed on lacking the H2A.Z-encoding gene with from generation to generation? It was mutants l