current self-reported symptoms of attention deficithyperactivity disorder are associated with total brain volume in healthy adults当前的自述症状注意deficithyperactivity障碍与健康成人大脑总额相关联.pdfVIP

Current Self-Reported Symptoms of Attention Deficit/ Hyperactivity Disorder Are Associated with Total Brain Volume in Healthy Adults 1,2 3 4 2 3,4 4 Martine Hoogman *, Mark Rijpkema , Luc Janss , Han Brunner , Guillen Fernandez , Jan Buitelaar , 1,2 ´ 1,2 Barbara Franke , Alejandro Arias-Vasquez 1 Department of Psychiatry, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands, 2 Department of Human Genetics, Radbound University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands, 3 Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands, 4 Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands Abstract Background: Reduced total brain volume is a consistent finding in children with Attention Deficit/Hyperactivity Disorder (ADHD). In order to get a better understanding of the neurobiology of ADHD, we take the first step in studying the dimensionality of current self-reported adult ADHD symptoms, by looking at its relation with total brain volume. Methodology/Principal Findings: In a sample of 652 highly educated adults, the association between total brain volume, assessed with magnetic resonance imaging, and current number of self-reported ADHD symptoms was studied. The results showed an association between these self-reported ADHD symptoms and total brain volume. Post