co-ordinated role of tlr3, rig-i and mda5 in the innate response to rhinovirus in bronchial epitheliumtlr3协同作用,rig - i和mda5先天反应在支气管上皮鼻病毒.pdfVIP

Co-ordinated Role of TLR3, RIG-I and MDA5 in the Innate Response to Rhinovirus in Bronchial Epithelium 1,2,3 1,2,3 1,2,3 4 1,5 Louise Slater , Nathan W. Bartlett , Jennifer J. Haas , Jie Zhu , Simon D. Message , Ross P. 1,2,3 1,2,3,5 1 3,6 3,6 Walton , Annemarie Sykes , Samer Dahdaleh , Deborah L. Clarke , Maria G. Belvisi , Onn M. 3,5 7 4 1,2,3,5 1,2,3 Kon , Takashi Fujita , Peter K. Jeffery , Sebastian L. Johnston , Michael R. Edwards * 1 Department of Respiratory Medicine, National Heart Lung Institute, Imperial College London, London, United Kingdom, 2 MRC Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom, 3 Centre for Respiratory Infection, London, United Kingdom, 4 Lung Pathology, National Heart Lung Institute, Imperial College London, London, United Kingdom, 5 Imperial Healthcare NHS Trust, London, United Kingdom, 6 Respiratory Pharmacology, National Heart Lung Institute, Imperial College London, London, United Kingdom, 7 Institute of Virus Research, Kyoto University, Kyoto, Japan Abstract The relative roles of the endosomal TLR3/7/8 versus the intracellular RNA helicases RIG-I and MDA5 in viral infection is much debated. We investigated the roles of each pattern recognition receptor in rhinovirus infection using primary bronchial epithelial cells. TLR3 was c