comparative analysis of the immunogenicity and protective effects of inactivated ev71 vaccines in mice比较分析的灭活ev71疫苗的免疫原性和保护效果的老鼠.pdfVIP

Comparative Analysis of the Immunogenicity and Protective Effects of Inactivated EV71 Vaccines in Mice 1 2 3 4 5 1 1 Qunying Mao , Chenghong Dong , Xiuling Li , Qiang Gao , Zengbing Guo , Xin Yao , Yiping Wang , 1 1 1 4 5 3 1 Fan Gao , Fengxiang Li , Miao Xu , Weidong Yin , Qihan Li , Xinliang Shen , Zhenglun Liang *, Junzhi Wang1* 1 National Institutes for Food and Drug Control, Beijing, China, 2 Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, China, 3 National Vaccine and Serum Institute, Beijing, China, 4 Sinovac Biotech Co., Ltd., Beijing, China, 5 Hualan Biological Engineering Inc, Henan, China Abstract Background: Enterovirus 71 (EV71) is the major causative agent of hand, foot, and mouth disease (HFMD). Three inactivated EV71 whole-virus vaccines of different strains developed by different manufacturers in mainland China have recently entered clinical trials. Although several studies on these vaccines have been published, a study directly comparing the immunogenicity and protective effects among them has not been carried out, which makes evaluating their relative effectiveness difficult. Thus, properly comparing newly developed vaccines has become a priority, especially in China. Methods and Findings: This comparative immunogenicity study was carried out on vaccine strains (both live and inactivated), final container products (FCPs) without adjuvant, and correspondin