comparative brain stem lesions on mri of acute disseminated encephalomyelitis, neuromyelitis optica, and multiple sclerosis比较脑干病变急性播散性脑脊髓炎的mri,视neuromyelitis和多发性硬化症.pdfVIP

Comparative Brain Stem Lesions on MRI of Acute Disseminated Encephalomyelitis, Neuromyelitis Optica, and Multiple Sclerosis 1. 1. 1. 2 1 1 Zhengqi Lu , Bingjun Zhang , Wei Qiu , Zhuang Kang , Liping Shen , Youming Long , Junqi 3 1 Huang *, Xueqiang Hu * 1 Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 2 Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 3 Key Laboratory of Tropical Diseases Control, Ministry of Education and Department of Immunology/Institute of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China Abstract Background: Brain stem lesions are common in patients with acute disseminated encephalomyelitis (ADEM), neuromyelitis optica (NMO), and multiple sclerosis (MS). Objectives: To investigate comparative brain stem lesions on magnetic resonance imaging (MRI) among adult patients with ADEM, NMO, and MS. Methods: Sixty-five adult patients with ADEM (n = 17), NMO (n = 23), and MS (n = 25) who had brain stem lesions on MRI were enrolled. Morphological features of brain stem lesions among these diseases were assessed. Results: Patients with ADEM had a higher frequency of midbrain lesions than did patients with NMO (94.1% vs. 17.4%, P,0.001) and MS (94.1% vs. 40.0%, P,0.001); patients with NMO had a lower frequency of pons lesions than did patients with MS (34.8% vs. 84.0%, P,0.001) and ADEM (34.8% vs. 70.6%, P = 0.025); and patients with NMO had a higher frequency of medulla oblongata lesions than did patients with ADEM (91.3% vs. 35.3%, P,0.001) and MS (91.3% vs. 36.0%, P,0.001). On the axial section of the brain stem, the majority (82.4%)