cinnamomum cassia bark in two herbal formulas increases life span in caenorhabditis elegans via insulin signaling and stress response pathways肉桂树皮在两个中药配方增加寿命线虫通过胰岛素信号和压力反应通路.pdfVIP

Cinnamomum cassia Bark in Two Herbal Formulas Increases Life Span in Caenorhabditis elegans via Insulin Signaling and Stress Response Pathways 1,4,5 1 2 3 6 1,2 Young-Beob Yu , Laura Dosanjh , Lixing Lao , Ming Tan , Bum Sang Shim , Yuan Luo * 1 Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, United States of America, 2 Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, Maryland, United States of America, 3 Division of Biostatistics, School of Medicine, University of Maryland, Baltimore, Maryland, United States of America, 4 Brain Disease Research Center, Korea Institute of Oriental Medicine, Daejeon, Korea, 5 Department of Medicinal Plant Resources, Nambu University, Gwangju, Korea, 6 College of Oriental Medicine, Kyunghee University, Seoul, Korea Abstract Background: Proving the efficacy and corresponding mode of action of herbal supplements is a difficult challenge for evidence-based herbal therapy. A major hurdle is the complexity of herbal preparations, many of which combine multiple herbs, particularly when the combination is assumed to be vitally important to the effectiveness of the herbal therapy. This issue may be addressed through the use of contemporary methodology and validated animal models. Methods and Principal Findings: In this study, two commonly used traditional herbal formulas, Shi Quan Da Bu Tang (SQDB) and Huo Luo Xiao Ling Dan (HLXL) were evaluated using a survival assay and oxidative stress biomarkers in a well-established C. elegans model of aging. HLXL is an eleven herb formula modified from a top-selling traditional