changes in crh and acth synthesis during experimental and human septic shockcrh的变化和acth合成实验和人类感染性休克.pdfVIP

Changes in CRH and ACTH Synthesis during Experimental and Human Septic Shock 1,2 3,4 ´ 3 5 6 Andrea Polito , Romain Sonneville , Celine Guidoux , Lucinda Barrett , Odile Viltart , Virginie 7 1,2 8 ´ 4 9 Mattot , Shidasp Siami , Geoffroy Lorin de la Grandmaison , Fabrice Chretien , Mervyn Singer , 3 1,2 3 1,2 Franc¸oise Gray , Djillali Annane *, Jean-Philippe Brouland , Tarek Sharshar ´ 1 Department of Intensive Care, Raymond Poincare Hospital, Garches, France, 2 Laboratory of Neuroendocrin Response to Sepsis, EA4342, University Versailles Saint- ` Quentin en Yvelines, Garches, France, 3 Department of Pathology, Lariboisiere Hospital, Paris, France, 4 Department of Infection and Epidemiology, HISTO (Human hISTOpathology and animal models), Pasteur Institute, Paris, France, 5 Department of Intensive Care, University College, London, United Kingdom, 6 Department of Biology, CNRS-UMR8161, Pasteur Institute of Lille, Lille, France, 7 Department of Plasticity of the Postnatal Brain, INSERM U837, University of Nord de France, Lille, France, ´ 8 Department of Pathology, Raymond Poincare Hospital, Garches, France, 9 Departement of Medicine, University College, London, United Kingdom Abstract Context: The mechanisms of septic shock-associated adrenal insufficiency rema