circadian clock genes contribute to the regulation of hair follicle cycling生物钟基因导致毛囊自行车的规定.pdfVIP

Circadian Clock Genes Contribute to the Regulation of Hair Follicle Cycling 1,2,3 4,5,6 1 3,7 7 Kevin K. Lin , Vivek Kumar , Mikhail Geyfman , Darya Chudova , Alexander T. Ihler , Padhraic Smyth3,7, Ralf Paus8,9, Joseph S. Takahashi4,5,6, Bogi Andersen1,2,3* 1 Department of Biological Chemistry, University of California Irvine, Irvine, California, United States of America, 2 Department of Medicine, University of California Irvine, Irvine, California, United States of America, 3 Institute for Genomics and Bioinformatics, University of California Irvine, Irvine, California, United States of America, 4 Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois, United States of America, 5 Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America, 6 Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, 7 Department of Computer Science, University of California Irvine, Irvine, California, United States of America, 8 Department of Dermatology, University of Luebeck, Luebeck, Germany, 9 School of Translational Medicine, University of Manchester, Manchester, United Kingdom Abstract Hair follicles undergo recurrent cycling of controlled growth (anagen), regression (catagen), and relative quiescence (telogen) with a defined periodicity. Taking a genomics approach to study gene expression during synchronized mouse hair follicle cycling, we discovered that, in addition to circadian fluctuation, CLOCK–regulated genes are also modulated in phase with the hair growth cycle. During telogen and early anagen, circadian clock genes are prominently expres