comparative and functional genomics of rhodococcus opacus pd630 for biofuels development比较和功能基因组学的红球菌属蔽光的pd630对生物燃料的发展.pdfVIP

Comparative and Functional Genomics of Rhodococcus opacus PD630 for Biofuels Development 1,2 1 1 2 2 Jason W. Holder , Jil C. Ulrich , Anthony C. DeBono , Paul A. Godfrey , Christopher A. Desjardins , 1,2 2 1 3 3 2 Jeremy Zucker , Qiandong Zeng , Alex L. B. Leach , Ion Ghiviriga , Christine Dancel , Thomas Abeel , 2 4 4 4 2 Dirk Gevers , Chinnappa D. Kodira , Brian Desany , Jason P. Affourtit , Bruce W. Birren , Anthony J. Sinskey1,5,6* 1 Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 2 The Broad Institute, Cambridge, Massachusetts, United States of America, 3 Department of Chemistry, University of Florida, Gainesville, Florida, United States of America, 4 454 Life Sciences, Branford, Connecticut, United States of America, 5 Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 6 Engineering Systems Division, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America Abstract The Actinomycetales bacteria Rhodococcus opacus PD630 and Rhodococcus jostii RHA1 bioconvert a diverse range of organic substrates through lipid biosynthesis into large quantities of energy-rich triacylglycerols (TAGs). To describe the genetic basis of the Rhodococcus oleaginous metabolism, we sequenced and performed comparative analysis of the 9.27 Mb R. opacus PD630 genome. M