原创力文档determination of baroreflex sensitivity during the modified oxford maneuver by trigonometric regressive spectral analysis压力反射敏感性测定在修改后的牛津机动三角倒退的光谱分析.pdfVIP
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determination of baroreflex sensitivity during the modified oxford maneuver by trigonometric regressive spectral analysis压力反射敏感性测定在修改后的牛津机动三角倒退的光谱分析
Determination of Baroreflex Sensitivity during the
Modified Oxford Maneuver by Trigonometric Regressive
Spectral Analysis
1 1,2 1 ¨ 1,2 1,2
Julia Gasch , Manja Reimann *, Heinz Reichmann , Heinz Rudiger , Tjalf Ziemssen
1 Autonomic and Neuroendocrinological Laboratory, Department of Neurology, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden,
Germany, 2 Research Group Neuro-Metabolism, Department of Neurology and Internal Medicine III, University Hospital Carl Gustav Carus, Dresden University of
Technology, Dresden, Germany
Abstract
Background: Differences in spontaneous and drug-induced baroreflex sensitivity (BRS) have been attributed to its different
operating ranges. The current study attempted to compare BRS estimates during cardiovascular steady-state and
pharmacologically stimulation using an innovative algorithm for dynamic determination of baroreflex gain.
Methodology/Principal Findings: Forty-five volunteers underwent the modified Oxford maneuver in supine and 60u tilted
position with blood pressure and heart rate being continuously recorded. Drug-induced BRS-estimates were calculated from
data obtained by bolus injections of nitroprusside and phenylephrine. Spontaneous indices were derived from data
obtained during rest (stationary) and under pharmacological stimulation (non-stationary) using the algorithm of
trigonometric regressive spectral analysis (TRS). Spontaneous and drug-induced BRS values were significantly correlated and
display directionally similar changes under different situations. Using the
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