development and field evaluation of a synthetic mosquito lure that is more attractive than humans开发和现场评价的合成蚊子吸引比人类更有吸引力.pdfVIP

Development and Field Evaluation of a Synthetic Mosquito Lure That Is More Attractive than Humans 1,2,3 1,4,5 1,3 1 Fredros O. Okumu *, Gerry F. Killeen , Sheila Ogoma , Lubandwa Biswaro , Renate C. 7 1 1 6 1 7 Smallegange , Edgar Mbeyela , Emmanuel Titus , Cristina Munk , Hassan Ngonyani , Willem Takken , 1 2 1,3,4 Hassan Mshinda , Wolfgang R. Mukabana , Sarah J. Moore 1 Biomedical and Environmental Sciences Thematic Group, Ifakara Health Institute, Ifakara, Tanzania, 2 School of Biological Sciences, University of Nairobi, Nairobi, Kenya, 3 Disease Control and Vector Biology Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom, 4 School of Biological Sciences, Durham University, Durham, United Kingdom, 5 Vector Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, 6 College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, United States of America, 7 Laboratory of Entomology, Wageningen University and Research Centre, Wageningen, The Netherlands Abstract Background: Disease transmitting mosquitoes locate humans and other blood hosts by identifying their characteristic odor profiles. Using their olfactory organs, the mosquitoes detect compounds present in human breath, sweat and skins, and use these as cues to locate and obtain blood from the humans. These odor compounds can be synthesized in vitro, then formulated to mimic humans. While some synthetic mosquito lures already exist, evidence supporting their utility is limited t