diabetes in danish bank voles (m. glareolus) survivorship, influence on weight, and evaluation of polydipsia as a screening tool for hyperglycaemia糖尿病在丹麦银行田鼠(m . glareolus)生存,影响体重,和评价烦渴的高血糖症的筛查工具.pdfVIP

Diabetes in Danish Bank Voles (M. glareolus): Survivorship, Influence on Weight, and Evaluation of Polydipsia as a Screening Tool for Hyperglycaemia 1 1 2 Bryan Schønecker *, Tonny Freimanis , Irene Vejgaard Sørensen 1 Department of Biology, University of Copenhagen, Copenhagen, Denmark, 2 Department of Veterinary Disease Biology, University of Copenhagen, Copenhagen, Denmark Abstract Background: Previous studies have concluded that the development of polydipsia (PD, a daily water intake $21 ml) among captive Danish bank voles, is associated with the development of a type 1 diabetes (T1D), based on findings of hyperglycaemia, glucosuria, ketonuria/-emia, lipemia, destroyed beta cells, and presence of autoantibodies against GAD65, IA-2, and insulin. Aim and Methods: We retrospectively analysed data from two separate colonies of Danish bank voles in order to 1) estimate survivorship after onset of PD, 2) evaluate whether the weight of PD voles differed from non-PD voles, and, 3), evaluate a state of PD as a practical and non-invasive tool to screen for voles with a high probability of hypeglycaemia. In addition, we discuss regional differences related to the development of diabetes in Scandinavian bank voles and the relevance of the Ljungan virus as proposed etiological agent. Results: We found that median survival after onset of PD is at least 91 days (lower/upper quartiles = 57/134 days) with a maximum recording of at least 404 days survivorship. The development of PD did not influence the weight of Danish bank voles. The measures of accuracy when using PD as predictor of hyperglycaemia, i.e. sensitivity, specificity, positive predictive value, and negative predictive value, equalled 69%,