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Direct Matrix-Assisted Laser Desorption Ionization Time- of-Flight Mass Spectrometry Improves Appropriateness of Antibiotic Treatment of Bacteremia Anne L. M. Vlek*, Marc J. M. Bonten, C. H. Edwin Boel Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands Abstract Matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) allows the identification of microorganisms directly from positive blood culture broths. Use of the MALDI-TOF MS for rapid identif