原创力文档discovery of a novel activator of kcnq1-kcne1 k+ channel complexes发现了一种新型活化剂kcnq1-kcne1 k +通道的复合物.pdfVIP
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discoveryofanovelactivatorofkcnq1-kcne1kchannelcomplexes发现了一种新型活化剂kcnq1-kcne1k通道的复合物
Discovery of a Novel Activator of KCNQ1-KCNE1 K+
Channel Complexes
Karen Mruk, William R. Kobertz*
Department of Biochemistry and Molecular Pharmacology, Programs in Neuroscience and Chemical Biology, University of Massachusetts Medical School, Worcester,
Massachusetts, United States of America
Abstract
KCNQ1 voltage-gated K+ channels (Kv7.1) associate with the family of five KCNE peptides to form complexes with diverse
gating properties and pharmacological sensitivities. The varied gating properties of the different KCNQ1-KCNE complexes
enables t
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