dietary manipulation and social isolation alter disease progression in a murine model of coronary heart disease饮食操纵和社会隔离改变疾病进展在冠心病的小鼠模型.pdfVIP

Dietary Manipulation and Social Isolation Alter Disease Progression in a Murine Model of Coronary Heart Disease Yumiko Nakagawa-Toyama.¤a, Songwen Zhang.¤b, Monty Krieger* Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America Abstract Background: Mice with a deficiency in the HDL receptor SR-BI and low expression of a modified apolipoprotein E gene (SR- BI KO/ApoeR61h/h) called ‘HypoE’ when fed an atherogenic, ‘Paigen’ diet develop occlusive, atherosclerotic coronary arterial disease (CHD), myocardial in