deregulation of hepatic insulin sensitivity induced by central lipid infusion in rats is mediated by nitric oxide放松管制的肝中央脂质灌注大鼠引起的胰岛素敏感性由一氧化氮介导的.pdfVIP

Deregulation of Hepatic Insulin Sensitivity Induced by Central Lipid Infusion in Rats Is Mediated by Nitric Oxide 1 1 2 3,4,5 6 ´ Nicolas Marsollier *, Nadim Kassis , Karima Mezghenna , Maud Soty , Xavier Fioramonti , Amelie 1 ´ 1 3,4,5 3,4,5 ´ 7 3,4,5 ´ 2 Lacombe , Aurelie Joly , Bruno Pillot , Carine Zitoun , Jose Vilar , Gilles Mithieux , Rene Gross , 2 6 1 ´ 1 Anne-Dominique Lajoix , Vanessa Routh , Christophe Magnan , Celine Cruciani-Guglielmacci ´ ´ ´ 1 CNRS-Universite Paris Diderot, Paris, France, 2 CNRS UMR 5232, Faculte de Pharmacie, Montpellier, France, 3 INSERM, U855, Lyon, France, 4 Universite de Lyon, U1235, Lyon, France, 5 Universite Claude Bernard Lyon I, Villeurbanne, France, 6 Department of Pharmacology and Physiology, New Jersey Medical School, Newark, New Jersey, ˆ ` United States of America, 7 INSERM U689, Hopital Lariboisiere, Paris, France Abstract Background: Deregulation of hypothalamic fatty acid sensing lead to hepatic insulin-resistance which may partly contribute to further impairment of glucose homeostasis. Methodology: We investigated here whether hypothalamic nitric oxide (NO) could mediate deleterious peripheral effect of central lipid overload. Thus we infus