disease-associated mutant ubiquitin causes proteasomal impairment and enhances the toxicity of protein aggregates疾病有关的突变体泛素蛋白酶体损伤原因和提高蛋白质总量的毒性.pdfVIP

Disease-Associated Mutant Ubiquitin Causes Proteasomal Impairment and Enhances the Toxicity of Protein Aggregates Elizabeth M. H. Tank, Heather L. True* Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, United States of America Abstract Protein homeostasis is critical for cellular survival and its dysregulation has been implicated in Alzheimer’s disease (AD) and other neurodegenerative disorders. Despite the growing appreciation of the pathogenic mechanisms involved in familial forms of AD, much less is known a