distinct impacts of eda and edar loss of function on the mouse dentitioneda的不同影响和edar损失函数的鼠标生齿.pdfVIP

Distinct Impacts of Eda and Edar Loss of Function on the Mouse Dentition 1¤ 2 3 4 2 5 Cyril Charles , Sophie Pantalacci , Paul Tafforeau , Denis Headon , Vincent Laudet , Laurent Viriot * ´ ´ ´ ´ 1 Institut International de Paleoprimatologie Paleontologie Humaine: Evolution et Paleoenvironnements UMR CNRS 6046, Universite de Poitiers, Poitiers, France, 2 Team ÆÆ ´ ´ ´ Molecular Zoology ææ, Institut de Genomique Fonctionnelle de Lyon, Universite de Lyon, UMR CNRS 5242, INRA, Universite Claude Bernard Lyon 1, Ecole Normale ´ Superieure de Lyon, Lyon, France, 3 European Synchrotron Radiation Facility, Grenoble, France, 4 The Roslin Institute and Royal (Dick) School of Veterinary Studies, ´ ´ University of Edinburgh, Edinburgh, United Kingdom, 5 Team ÆÆ Evo-Devo of Vertebrate Dentition ææ, Institut de Genomique Fonctionnelle de Lyon, Universite de Lyon, ´ ´ UMR CNRS 5242, INRA, Universite Claude Bernard Lyon 1, Ecole Normale Superieure de Lyon, Lyon, France Abstract Background: The Eda-A1-Edar signaling pathway is involved in the development of organs with an ectodermal origin, including teeth. In mouse, mutants are known for both the ligand, Eda-A1 (Tabby), and the receptor, Edar (Downless). The adult dent