differential sialylation of serpin a1 in the early diagnosis of parkinson’s disease dementia微分sialylation serpin a1在帕金森病痴呆的早期诊断.pdfVIP

Differential Sialylation of Serpin A1 in the Early Diagnosis of Parkinson’s Disease Dementia 1. 1. 2,3 4 5 5 Sarah Jesse , Stefan Lehnert , Olaf Jahn , Lucilla Parnetti , Hilkka Soininen , Sanna-Kaisa Herukka , 1 1 1 1 6 Petra Steinacker , Saskia Tawfik , Hayrettin Tumani , Christine A. F. von Arnim , Manuela Neumann , 7 8 9 10 9 Hans A. Kretzschmar , Hasan Kulaksiz , Martin Lenter , Jens Wiltfang , Boris Ferger , 9 1 Bastian Hengerer , Markus Otto * 1 Department of Neurology, University of Ulm, Ulm, Germany, 2 Proteomics Group, Max-Planck-Institute for Experimental Medicine, Goettingen, Germany, 3 DFG Research Center for Molecular Physiology of the Brain, Goettingen, Germany, 4 Department of Neurology, University of Perugia, Perugia, Italy, 5 Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland, 6 Institute of Neuropathology, University of Zurich, Zurich, Switzerland, 7 Institute of Neuropathology, Ludwig Maximilians University, Munich, Germany, 8 Department of Internal Medicine, University of Ulm, Ulm, Germany, 9 CNS Diseases Research, Boehringer Ingelheim GmbH Co. KG, Biberach an der Riss, Germany, 10 Department of Psychiatry, University of Essen-Duisburg, Essen-Duisburg, Germany Abstract The prevalence of Parkinson’s disease (PD) increases with age. Up to 50% of