development and validation of a new questionnaire assessing quality of life in adults with hypopituitarism adult hypopituitarism questionnaire (ahq)开发和验证一个新的问卷调查评估与垂体机能减退成人垂体机能减退成年人的生活质量问卷(ahq).pdfVIP

Development and Validation of a New Questionnaire Assessing Quality of Life in Adults with Hypopituitarism: Adult Hypopituitarism Questionnaire (AHQ) 1 2 3 4 5 6 Hitoshi Ishii *, Akira Shimatsu , Yasuhiko Okimura , Toshiaki Tanaka , Naomi Hizuka , Hidesuke Kaji , 7 8 1 9 10 Kunihiko Hanew , Yutaka Oki , Sayuri Yamashiro , Koji Takano , Kazuo Chihara 1 Department of Endocrinology, Tenri Hospital, Tenri, Japan, 2 Clinical Research Institute, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan, 3 Department of Nutrition, Metabolism and Food Science, Graduate School of Life Science, Kobe Women’s University, Kobe, Japan, 4 Tanaka Growth Clinic, Tokyo, Japan, 5 Department of Medicine II, Tokyo Women’s Medical University, Tokyo, Japan, 6 Division of Physiology/Metabolism, University of Hyogo, Akashi, Japan, 7 Hanew Endocrine Clinic, Sendai, Japan, 8 Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan, 9 Department of Nephrology and Endocrinology, the University of Tokyo Faculty of Medicine, Tokyo, Japan, 10 Department of Diabetes and Endocrinology, Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Japan Abstract Objective: To develop and validate the Adult Hypopituitarism Questionnaire (AHQ) as a disease-specific, self-administered questionnaire for evaluation of quality of life (QOL) in adult patients with hypopituitarism. Methods: We developed and validated this new questionnaire, using a standardized procedure which included item development, pilot-testing and psychometric validation. Of the patients who participated in psychometric validation, those