deficient of a clock gene, brain and muscle arnt-like protein-1 (bmal1), induces dyslipidemia and ectopic fat formation不足的生物钟基因,大脑和肌肉arnt-like蛋白1(bmal1),导致血脂异常和异位脂肪形成.pdfVIP

Deficient of a Clock Gene, Brain and Muscle Arnt-Like Protein-1 (BMAL1), Induces Dyslipidemia and Ectopic Fat Formation 1 1 1 1 1 Shigeki Shimba *, Tomohiro Ogawa , Shunsuke Hitosugi , Yuya Ichihashi , Yuki Nakadaira , Munehiro 1 1 2 2 2 3 Kobayashi , Masakatsu Tezuka , Yasuhiro Kosuge , Kumiko Ishige , Yoshihisa Ito , Kazuo Komiyama , 4 4 5 Yuko Okamatsu-Ogura , Kazuhiro Kimura , Masayuki Saito 1 Department of Health Science, School of Pharmacy, Nihon University, Funabashi, Chiba, Japan, 2 Department of Pharmacology, School of Pharmacy, Nihon University, Funabashi, Chiba, Japan, 3 Department of Pathology, School of Dentistry, Nihon University, Tokyo, Japan, 4 Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita-ku, Sapporo, Japan, 5 Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo, Japan Abstract A link between circadian rhythm and metabolism has long been discussed. Circadian rhythm is controlled by positive and negative transcriptional and translational feedback loops composed of several clock genes. Among clock genes, the brain and muscle Arnt-like protein-1 (BMAL1) and circadian locomotor output cycles kaput (CLOCK) play important roles in the regulation of the positive rhythmic transcription. In addition to control of circadian rhythm, we have previously shown that BMAL1 regulates adipogenesis. In metabolic syndrome patients, the function of BMAL1 is dysregulated in visceral adipose tissue. In addition, analysis of SNPs has reve