down-regulation of ecrg4, a candidate tumor suppressor gene, in human breast cancerecrg4下调,候选肿瘤抑制基因,在人类乳腺癌.pdfVIP

Down-Regulation of ECRG4, a Candidate Tumor Suppressor Gene, in Human Breast Cancer 1,2 1 ´ 1 1 3,4 1 Renaud Sabatier , Pascal Finetti , Jose Adelaide , Arnaud Guille , Jean-Paul Borg , Max Chaffanet , 5,6 1 1,2,3 Lydie Lane , Daniel Birnbaum , Franc¸ois Bertucci * ´ ´ ´ 1 Departement d’Oncologie Moleculaire, Centre de Recherche en Cancerologie de Marseille, UMR891 INSERM and Institut Paoli-Calmettes Marseille, Marseille, France, ´ ´ ´ ´ 2 Departement d’Oncologie Medicale, Centre de Recherche en Cancerologie de Marseille, Institut Paoli-Calmettes Marseille, Marseille, France, 3 Universite de la ´ ´ ´ ´ ´ Mediterranee, Marseille, France, 4 Departement de Polarite cellulaire, signalisation et cancer, Centre de Recherche en Cancerologie de Marseille, U891 INSERM and Institut Paoli-Calmettes Marseille, Marseille, France, 5 SIB-Swiss Institute of Bioinformatics, Geneva, Switzerland, 6 Department of Human Protein Science, University of Geneva, Geneva, Switzerland Abstract Introduction: ECRG4/C2ORF40 is a potential tumor suppressor gene (TSG) recently identified in esophageal carcinoma. Its expression, gene copy number and prognostic value have never been explored in breast cancer. Methods: Using DNA microarray and array-based comparative genomic hybrid