dissociation between the activity of the right middle frontal gyrus and the middle temporal gyrus in processing semantic priming活动之间的分离右侧额中回和颞中回处理语义启动.pdfVIP

Dissociation between the Activity of the Right Middle Frontal Gyrus and the Middle Temporal Gyrus in Processing Semantic Priming 1 1 1 1,2 1,2 Ilan Laufer *, Michiro Negishi , Cheryl M. Lacadie , Xenophon Papademetris , R. Todd Constable 1 Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, United States of America, 2 Department of Biomedical Engineering, Yale University, New Haven, Connecticut, United States of America Abstract The aim of this event-related functional magnetic resonance imaging (fMRI) study was to test whether the right middle frontal gyrus (MFG) and middle temporal gyrus (MTG) would show differential sensitivity to the effect of prime-target association strength on repetition priming. In the experimental condition (RP), the target occurred after repetitive presentation of the prime within an oddball design. In the control condition (CTR), the target followed a single presentation of the prime with equal probability of the target as in RP. To manipulate semantic overlap between the prime and the target both conditions (RP and CTR) employed either the onomatopoeia ‘‘oink’’ as the prime and the referent ‘‘pig’’ as the target (OP) or vice-versa (PO) since semantic overlap was previously shown to be greater in OP. The results showed that the left MTG was sensitive to release of adaptation while both the right MTG and MFG were sensitive to sequence regularity extraction and its verification. However, dissociated activity between OP and PO was revealed in RP only in the right MFG. Specifically, target ‘‘pig’’ (OP) and the physically equivalent target in CTR elicited comparable deactivations wh