differential micro rna expression in pbmc from multiple sclerosis patients差微rna表达从多发性硬化症患者pbmc.pdfVIP

Differential Micro RNA Expression in PBMC from Multiple Sclerosis Patients 1 2 ˜ 3 3 ˜ 1 David Otaegui *, Sergio E. Baranzini , Ruben Armananzas , Borja Calvo , Maider Munoz-Culla , Puya 2 ˜ 3 3 ˜ 1,4 1,4 Khankhanian , Inaki Inza , Jose A. Lozano , Tamara Castillo-Trivino , Ana Asensio , Javier 1,4 ´ 1,4 Olaskoaga , Adolfo Lopez de Munain ´ 1 Multiple Sclerosis Unit, Biodonostia Institute, San Sebastian, Spain, 2 Neurology Department, University of California San Francisco, San Francisco, California, United ´ States of America, 3 Intelligent Systems Group, Computer Science Faculty, University of the Basque Country, San Sebastian, Spain, 4 Neurology Department, Hospital ´ Donostia, San Sebastian, Spain Abstract Differences in gene expression patterns have been documented not only in Multiple Sclerosis patients versus healthy controls but also in the relapse of the disease. Recently a new gene expression modulator has been identified: the microRNA or miRNA. The aim of this work is to analyze the possible role of miRNAs in multiple sclerosis, focusing on the relapse stage. We have analyzed the expression patterns of 364 miRNAs in PBMC obtained from multiple sclerosis patients in relapse status, in remission status and healthy contro